Related Research on Enterovirus
The dysfunction of gut microbiota is related to the production of inflammatory bowel disease.
Past research attempts to explore the role of microbes in IBD have focused on the bacteria themselves, but there's also a virus in the intestine that's mostly made up of prokaryotic viruses, called phages. When IBD occurs, the number and variety of phages in the small intestinal mucosa increases, meaning that phages play an unknown role in the development of IBD.
Scientists from the University of Colorado School of Medicine recently used a sequence-independent approach to select viral contigs in a mouse enteritis model, then used quantitative metagenomics to study intestinal phages. The researchers found that the population of intestinal phages changed during enteritis from an orderly state to a random disorder.
The researchers also found specific phages associated with enteric disease, whose numbers and populations change during the disease. In addition, there is an overlap between phage species in the intestine of healthy and diseased mice and phage populations in the intestine of healthy people and patients with IBD.
Therefore, this study suggests that intestinal phage populations change during inflammatory diseases, this established a new method for studying phages involving IBD.
Past research attempts to explore the role of microbes in IBD have focused on the bacteria themselves, but there's also a virus in the intestine that's mostly made up of prokaryotic viruses, called phages. When IBD occurs, the number and variety of phages in the small intestinal mucosa increases, meaning that phages play an unknown role in the development of IBD.
Scientists from the University of Colorado School of Medicine recently used a sequence-independent approach to select viral contigs in a mouse enteritis model, then used quantitative metagenomics to study intestinal phages. The researchers found that the population of intestinal phages changed during enteritis from an orderly state to a random disorder.
The researchers also found specific phages associated with enteric disease, whose numbers and populations change during the disease. In addition, there is an overlap between phage species in the intestine of healthy and diseased mice and phage populations in the intestine of healthy people and patients with IBD.
Therefore, this study suggests that intestinal phage populations change during inflammatory diseases, this established a new method for studying phages involving IBD.
